Dr. Harvey’s Science News for May

Branched-Chain Amino Acids Reduce Muscle Damage

The aim of this study was to examine the effects of a BCAA supplementation on markers of muscle damage elicited via a sport specific bout of damaging exercise in trained volunteers. Twelve males were randomly assigned to a supplement (n = 6) or placebo (n = 6) group. The amaging exercise consisted of 100 consecutive drop-jumps. Creatine kinase (CK), maximal voluntary contraction, muscle soreness (DOMS), vertical jump, thigh circumference and calf circumference were measured as markers of muscle damage. All variables were measured immediately before the damaging exercise and at 24, 48, 72 and 96 hours post-exercise. There were significant group effects showing a reduction in CK efflux and muscle soreness in the BCAA group compared to the placebo. The present study has shown that BCAA administered before and following damaging resistance exercise reduces indices of muscle damage and accelerates recovery in resistance trained males. (Howatson G, et al. J Int Soc Sports Nutr. 2012 8;9:20). MMSN Featured Products: Max BCAA and ARM


The aim of this study was to investigate the effects of beta-alanine supplementation on exercise capacity and the muscle carnosine content in elderly subjects. Eighteen healthy elderly subjects ages 60-80 years were randomly assigned to receive either betaalanine (BA) or placebo (PL) for 12 weeks. The BA group received 3.2 g of beta-alanine per day. The PL group received a matched placebo. At baseline, assessments were made of the muscle carnosine content, anaerobic exercise capacity, muscle function, quality of life, physical activity and food intake. A significant increase in the muscle carnosine content of the gastrocnemius muscle was shown in the BA group (+85.4%) when compared with the PL group (+7.2%). The time-to-exhaustion in the constant-load submaximal test (i.e., TLIM) was significantly improved (p=0.05; ES: 1.71) in the BA group (+36.5%) versus the PL group (+8.6%). In summary, the current data indicate for the first time that beta-alanine supplementation is effective in increasing the muscle carnosine content in healthy elderly subjects, with subsequent improvement in their exercise capacity. (del Favero S, et al. Amino Acids. 2012;43:49-56). MMSN Featured Product: Xtinguisher

PEA PROTEIN May Lower Cholesterol at the Gene Level

Researchers set out to evaluate a possible lipid lowering activity of a pea protein isolate and to determine whether pea proteins could affect the hepatic lipid metabolism through regulation of genes involved in cholesterol and fatty acid homeostasis. Rats were fed special high cholesterol diets for 28 days, the protein sources being casein or a pea protein isolate. After 14 and 28 days of dietary treatment, rats fed pea proteins had markedly lower plasma cholesterol and triglyceride levels than rats fed casein (p<0.05). Pea protein-fed rats displayed higher hepatic mRNA levels of LDL receptor versus those fed casein (p<0.05). Hepatic mRNA concentration of genes involved in fatty acids synthesis were lower in pea protein-fed rats than in rats fed casein (p<0.05). The present study demonstrates a marked cholesterol and triglyceride-lowering activity of pea proteins in rats. Moreover, pea proteins appear to affect cellular lipid homeostasis by upregulating genes involved in hepatic cholesterol uptake and by downregulating fatty acid synthesis genes. (Rigamonti E. et al. Mol Nutr Food Res. 2010;54:S24-30). MMSN Featured Product: COMP

Yours In Health,
Phillip W. Harvey, PhD, RD, FACN, CNS
Chief Scientific Officer
Max Muscle Corporate USA

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