Dr. Harvey’s Science News November

Leucine Supplementation May be Key Amino Acid in Weight Loss

Scientific evidence supports that high protein diets favor weight loss and its maintenance. Leucine, as a member of the branched-chain amino acid family, is hypothesized as playing a significant role. To investigate this, researchers conducted a study in obese mice to look at the impact of leucine supplementation on energy balance and associated metabolic changes. Mice were fed either a normal caloric diet while receiving the amino acid leucine or no leucine in drinking water. Researchers found that the mice fed the leucine supplementation had decreased body weight and fat mass. Additionally, mice supplemented with leucine had improved glucose tolerance, increased leptin sensitivity and lower respiratory quotient. These research scientists concluded that leucine supplementation might represent an adjuvant beneficial nutritional therapy during weight loss and maintenance, because it improves lipid and glucose metabolism and restores leptin sensitivity in previously obese animals. (Binder E, Bermudez-Silva FJ, Elie M, et al. Obesity. 2013 Jul 25. Doi:10.1002/oby.20578). MMSN Featured Product: Pro BCAA

Recent Study Supports More Protein for More Muscle

It appears that increased protein protects against muscle breakdown during diet and weight loss programs. The purpose of this study was to determine the effects of varying levels of dietary protein on body composition and muscle protein synthesis during energy deficit periods. Researchers at the U.S. Army Research Institute at Natick, MA conducted a randomized controlled trial of 39 adults assigned the subjects diets providing protein at 0.8 Recommended Dietary Allowance [RDA], 1.6 (2x-RDA), and 2.4 (3x-RDA) grams per kilograms of body weight per day for 31 days.. Researchers found that the proportion of weight loss due to reductions in fat-free mass was significantly lower and the loss of fat mass was higher in those receiving 2×-RDA and 3×-RDA compared to RDA. Researchers concluded that consuming dietary protein at levels exceeding the RDA may protect fat-free mass during short-term weight loss. (Pasiakos SM, Cao JJ, Margolis LM, et al. FASEB J. 2013;27:3837-47). MMSN Featured Products: MaxPro or Triple Whey

Tribulus Terrestris Does Not Lead to a Positive Drug Test

Some critics claim Tribulus terrestris may increase the urinary testosterone/epitestosterone (T/E) ratio, which may place athletes at risk of a positive drug test. To test this hypothesis, researchers at the Southern Cross University, NSW, Australia conducted a study to determine the effect of T. terrestris on strength, fat-free mass, and the urinary T/E ratio during 5 weeks of preseason training in elite rugby league players. Twenty-two players were match-paired and randomly assigned to either a T. terrestris (450mg/d) or placebo group. All subjects performed structured heavy resistance training as part of the club’s preseason preparations. After 5 weeks of training, strength and fat free mass increased significantly without any between-group differences. Researchers concluded T. terrestris did not alter the urinary T/E ratio and would not place an athlete at risk of testing positive based on the World Anti-Doping Agency’s urinary T/E ratio limit of 4:1. (Rogerson S, Riches CJ, Jennings C, et al. J Strength Cond Res. 2007;21:348-53). MMSN Featured Product: Max Tribustak

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Dr. Harvey’s Science News October

Slimaluma Effective As Anti-Obesity and Appetite Suppressor Herb
The main objective of this article was to review the studies undertaken on the plant in light of further research for anti-obesity compounds from species of Caralluma. Caralluma fimbriata extract has received Generally Recognized As Safe (GRAS) status for use as a nutraceutical to combat obesity as one of the most serious public health concerns in adults. An extract of C. fimbriata (Slimaluna) is used as an anti-obesity agent and appetite suppressor. On reviewing the studies undertaken on the chemistry, pharmacology and therapeutic potential of Caralluma, it is concluded that the genus contains bioactive pregnane glycosides as one of the major constituents shown to have anti-obesity and appetite suppressor effects. This coupled with the GRAS status of the extract of C. fimbriata has opened the possibility of developing an anti-obesity/appetite-suppressant product from other species of Caralluma. (Dutt HC, Singh S, Avula B, Khan IA, Bedi YS. J Med Food. 2012 15:108-9). MMSN Featured Products: Femme Lean & Balance, Cleanse & Lean Advanced and Quadra Cuts Competition

Creatine Supplementation Post-Workout Superior to Pre-Workout on Body Composition and Strength
Researchers conducted a study to determine the difference between pre versus post exercise supplementation of creatine on measures of body composition and strength. Nineteen healthy male bodybuilders participated in this study and subjects were randomly assigned to one of the following groups: Pre-Supp group consumed 5 g of creatine immediately before exercise, Post-Supp group consumed 5 g immediately after exercise. Subjects performed a periodized, split-routine, bodybuilding workout five days per week for four weeks. Researchers found and concluded that creatine supplementation plus resistance exercise increases fat-free mass and strength and it appears that consuming creatine immediately post-workout is superior to pre-workout on body composition and strength. (Antonio J, Ciccone V. J Int Soc Sports Nutr. 2013;10:36). Featured MMSN Product: ARM

Ashwagandha Safe and Effective in Stress Reduction
Ashwagandha has been proven as a safe and effective adaptogen. Adaptogens are herbs that help in combating stress. The aim of the study was to evaluate the safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha root in reducing stress and anxiety and in improving the general well-being of adults who were under stress. Sixty four subjects with a history of chronic stress were enrolled into the study and were randomized to either the placebo control group or the study treatment group for a period of 60 days. Subjects in the study treatment group were instructed to take one capsule twice daily containing 300mg of high-concentration full-spectrum Ashwagandha extract. Researchers found that the treatment group exhibited a significant reduction in scores on all the stress-assessment scales on Day 60. The serum cortisol levels were substantially reduced in the Ashwagandha group compared to the placebo group. The findings of this study suggest that a high-concentration full-spectrum Ashwagandha root extract safely and effectively improves an individual’s resistance towards stress and thereby improves self-assessed quality of life. (Chandrasekhar K, Kapoor J, Anishetty S. Indian J Psychol Med. 2012;34:255-62). MMSN Featured Product: ADRX

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Dr Harvey’s Science News September

Alpha-GPC Increases GH Secretion and Fat Burning
Alpha-Glycerophosphocholine (A-GPC) is an acetylcholine precursor that potentially increases growth hormone (GH) secretion. Researchers at Ritsumeikan University, Shiga, Japan conducted a study to investigate acute physiologic responses to a single intake of A-GPC. Eight healthy adult males ingested either 1000 mg A-GPC or a placebo in a double-blind randomized crossover study. Research found plasma free choline levels significantly increased at 60 and 120 min after A-GPC administration. Plasma GH secretion was increased significantly 60 min after taking A-GPC, whereas no significant change was observed with the placebo. Serum free fatty acid increased 120 min after A-GPC ingestion, but no changes were seen with the placebo. Moreover, indices of hepatic fat oxidation were increased at 120 min after taking A-GPC, whereas the placebo had no effect. These findings suggest that a single dose of A-GPC increases GH secretion and hepatic fat oxidation, with concomitant increases in choline levels, in young adults. (Kawamura T, Okubo T, Sato K, et al. Nutrition. 2012;28:1122-6) MMSN Featured Product: GHTX

Skipping Breakfast is Common in Adolescents and is Strongly Associated with Obesity
Researchers from the University of Missouri School of Medicine conducted a randomized crossover design study in which 20 adolescent girls consumed a normal protein cereal breakfast (350 Kcal, 13 g protein), a high protein cereal breakfast (350 Kcal, 35 g protein), or no breakfast for 6 days. On day 7, a 10-h testing day was completed that included appetite and satiety questionnaires, blood sampling, pre-dinner food cue-stimulated functional magnetic resonance imaging brain scans, ad libitum dinner and evening snacking. Researchers found that breakfast led to beneficial alterations in the appetitive, hormonal and neural signals that control food intake regulation. These data suggest that the addition of breakfast, particularly one rich in protein, might be a useful strategy to improve satiety, reduce food motivation and reward, and improve diet quality in overweight or obese teenage girls. (Leidy HJ, Ortinau LC, Douglas SM, Hoertel HA. Am J Clin Nutr. 2013;97:677-88) MMSN Featured Products: MaxPro, Triple Whey, Gourmet Protein

D-Aspartic Acid (DAA) Enhances LH and Testosterone Release
Researchers investigated the effects of D-aspartic acid (DAA) on the release of LH and testosterone in the serum of humans and rats and the role of DAA in the synthesis of LH and testosterone in the pituitary and testes and the molecular mechanisms by which this amino acid triggers its action. From the human study, a group of 23 men were given a daily dose of DAA for 12 days, whereas another group of 20 men were given a placebo. These researchers found DAA induces an enhancement of LH and testosterone release in pituitary glands. The molecular mechanisms studied in rats showed the release and synthesis of LH is mediated through the involvement of cGMP in the pituitary as a second messenger testosterone release in the Leydig cells by cAMP as a second messenger. Both the pituitary and testes possesses a high capacity to trapping circulating DAA. Researchers concluded DAA is a physiological amino acid occurring principally in the pituitary gland and testes and has a role in the regulation of the release and synthesis of LH and testosterone in humans. (Topo E, Soricelli A, D’Aniello A, Ronsini S, D’Aniello G. Reprod Biol Endocrinol. 2009;27:7) MMSN Featured Product: MTX

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Dr. Harvey’s Science News August

Mytosterone Found Superior for Testosterone Support
Testosterone (T) levels decline as men age that can have dramatic effects on overall health and physical performance. Mytosteronel, a patented matrix supplying Saw Palmetto Berry Extract (Serenoa repens) and Astaxanthin Extract (Haematococccus pluvialis), has been reported to inhibit the enzyme 5-alpha reductase (5AR) and aromatase (AER), the two major enzymes that regulate serum T increases and concomitant decreases in DHT resulting in anti-aromatase mechanisms. To investigate this clinically, 42 healthy males ages 37 to 70 years were divided into two groups of 21 and dosed with either 800 mg/day or 2,000 mg/day of Mytosterone for 14 days. Blood samples were collected on days 0, 3, 7 and 14 and assayed for T, DHT and estrogen. Both dose groups showed significant increases in T and decreases in DHT within three days of treatment with Mytosterone. Between group statistical analysis showed no significant difference, indicating the effect was not dose dependent and that 800 mg/per day is equally effective as 2,000 mg/day for increasing T and lowering DHT. Blood levels of estrogen decreased significantly in the 2,000 mg/day dose group but not in the 800 mg/day dose group indicating a dose dependent decrease in estrogen levels. (Fru A, Anderson ML. J Int Soc Sports Nutr. 2008; 5:12) MMSN Featured Product: MTX

Whey Protein Isolate Shown To Counteract Effects of High-Fat Diets
The intake of whey protein isolate (WPI) is known to reduce high-fat diet induced body weight gain and body fat. However, the molecular mechanisms are not fully understood. To this end, scientists from the Teagasc Food Research Centre in Ireland fed mice for 8 weeks diets containing 10 percent energy as fat (low-fat diet) or 45 percent energy as fat (high-fat diet) enriched with either 20 percent energy as casein or WPI. They found the high-fat diet increased body fat mass, plasma leptin (hormone that regulates fat metabolism) levels, meal number, respiratory exchange rate (RER), metabolic (VO2 and heat) and locomotor activities compared with the low-fat diet. The high fat diet increased the hypothalamic tissue mRNA expression of the leptin receptor and insulin receptor. In contrast, WPI reduced fat mass and reduced meal size in the high-fat fed mice. These researchers concluded that in comparison with casein, the effects of WPI on energy intake and hypothalamic and adipose tissue gene expression may thus represent a state of reduced susceptibility to weight gain on a high fat diet. (McAllan L, Keane D, Schellenkens H, et al. Br J Nutr. 2013; 4:1-13) MMSN Featured Product: ISOX and ISO Extreme

Omega-3 Fatty Acids May Slow the Aging Process
Shorter telomeres have been associated with poor health behaviors, age-related diseases, and early mortality. Telomere length is regulated by the enzyme telomerase, and is linked to exposure to pro-inflammatory cytokines and oxidative stress. Researchers from The Ohio State University conducted a double-blind four-month trial, which included 106 healthy sedentary, overweight, middle-aged and older adults who received 2.5g/day omega-3 PUFAs, l.25g/day omega-3 PUFAs, or placebo capsules that mirrored the proportions of fatty acids in the typical American diet. Supplementation significantly lowered oxidative stress as measured by F2-isoprostanes. Although group differences for telomerase and telomere length were non-significant, telomere length increased with omega-3 PUFA ratios. The data suggests that lower omega-6:omega-3 PUFA ratios can impact cell aging. The triad of inflammation, oxidative stress and immune cell aging represents important mechanisms that may be ameliorated through nutritional interventions. (Kiecolt-Glaser JK, Epel ES, Belury MA, et al. Brain Behav Immun. 2013; 28:16-24) MMSN Featured Product: Essential Omega. MN Featured Product: Omega 3 PLUS

Yours In Health,
Phillip W. Harvey, PhD, RD, FACN, FISSN
Chief Scientific Officer
Max Muscle Corporate USA

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Dr. Harvey’s Science News July 2013

Whey Protein Isolate Shown to Counteract Effects of High-Fat Diets
The intake of whey protein isolate (WPI) is known to reduce high-fat diet induced body weight gain and body fat. However, the molecular mechanisms are not fully understood. To this end, scientists from the Teagasc Food Research Centre in Ireland fed mice for 8 weeks diets containing 10% energy as fat (low-fat diet) or 45% energy as fat (high-fat diet) enriched with either 20% energy as casein or WPI. They found the high-fat diet increased body fat mass, plasma leptin (hormone that regulates fat metabolism) levels, meal number, respiratory exchange rate (RER), metabolic (VO2 and heat) and locomotor activities compared with the low-fat diet. The high fat diet increased the hypothalamic tissue mRNA expression of the leptin receptor and insulin receptor. In contrast, WPI reduced fat mass, reduced meal size in the high-fat fed mice. These researchers concluded that in comparison with casein, the effects of WPI on energy intake and hypothalamic and adipose tissue gene expression may thus represent a state of reduced susceptibility to weight gain on a high fat diet. (McAllan L, Keane D, Schellenkens H, et al. Br J Nutr. 2013;4:1-13) MMSN Featured Product: ISOX and ISO Extreme

Mytosterone® Found Superior for Testosterone Support
Testosterone (T) levels decline as men age that can have dramatic effects on overall health and physical performance. Mytosterone® (Patented Matrix Supplying: Saw Palmetto Berry Extract (Serenoa repens) and Astaxanthin Extract (Haematococccus pluvialis) has been reported to inhibit the enzyme 5-alpha reductase (5AR) and aromatase (AER), the two major enzymes that regulate serum T increases and concomitant decreases in DHT resulting in anti-aromatase mechanisms. To investigate this clinically, 42 healthy males ages 37 to 70 years were divided into two groups of twenty-one and dosed with either 800 mg/day or 2000 mg/day of Mytosterone® for fourteen days. Blood samples were collected on days 0, 3, 7 and 14 and assayed for T, DHT and estrogen. Both dose groups showed significant increases in T and decreases in DHT within three days of treatment with Mytosterone®. Between group statistical analysis showed no significant difference, indicating the effect was not dose dependent and that 800 mg/per day is equally effective as 2000 mg/day for increasing T and lowering DHT. Blood levels of estrogen decreased significantly in the 2000 mg/day dose group but not in the 800 mg/day dose group indicating a dose dependent decrease in estrogen levels. (Fru A, Anderson ML. J Int Soc Sports Nutr. 2008;5:12) MMSN Featured Product: MTX

Omega-3 Fatty Acids May Slow the Aging Process

Shorter telomeres have been associated with poor health behaviors, age-related diseases, and early mortality. Telomere length is regulated by the enzyme telomerase, and is linked to exposure to pro-inflammatory cytokines and oxidative stress. Researchers from The Ohio State University conducted a double-blind four month trial included 106 healthy sedentary overweight middle-aged and older adults who received 2.5g/day omega-3 PUFAs, l.25g/day omega-3 PUFAs, or placebo capsules that mirrored the proportions of fatty acids in the typical American diet. Supplementation significantly lowered oxidative stress as measured by F2-isoprostanes. Although group differences for telomerase and telomere length were non-significant, telomere length increased with omega-3 PUFA ratios. The data suggest that lower omega-6:omega-3 PUFA ratios can impact cell aging. The triad of inflammation, oxidative stress and immune cell aging represents important mechanisms that may be ameliorated through nutritional interventions. (Kiecolt-Glaser JK, Epel ES, Belury MA, et al. Brain Behav Immun. 2013;28:16-24. MMSN Featured Product: Essential Omega. MN Featured Product: Omega 3 PLUS.

Yours In Health,
Phillip W. Harvey, PhD, RD, FACN, FISSN
Chief Scientific Officer
Max Muscle Corporate USA

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Dr. Harvey’s Science News for June

Dr. Phil Harvey is a leading expert in nutritional biochemistry and has been involved in education, research and the nutritional industry for over 30 years. Dr. Harvey is the Chief Scientific Officer for Max Muscle Sports Nutrition and heads product research and development, regulatory affairs, QA/QC, technical writing in addition to responsibilities in education and training.

Dr. Harvey received his Ph.D. from Colorado State University and M.S.P.H. degree from the UCLA School of Public Health. He was awarded a post-doctoral fellowship in the UCLA Department of Medicine & Molecular Biology Institute. He is a Registered Dietitian, Certified Nutrition Specialist and elected a Fellow of the American College of Nutrition and Fellow of the International Society of Sports Nutrition. Dr. Harvey is a member of numerous professional organizations including the International Society for Sports Nutrition, American Society for Nutrition, Academy of Nutrition and Dietetics and Institute of Food Technologists.

Dr. Harvey was also invited to serve on the Editorial Board of the prestigious Journal of the ISSN and on the Advisory Board of the ISSN.

Higher CoQ10 and B6 Levels Linked to Reduced Risk of Coronary Artery Disease
Researchers at the School of Nutrition, Chung Shan Medical University in Taichung, Taiwan, investigated the relationship between plasma levels of coenzyme Q10 (CoQ10) and vitamin B6 and the risk of coronary artery disease. The study consisted of a control group of healthy individuals with normal blood biochemistry and a case group comprised of patients with at least 50 percent blockage of one major coronary artery identified by cardiac catheterization. The researchers discovered that there was a significant inverse correlation between higher plasma levels of CoQ10 and vitamin B6 and a reduced risk of coronary artery disease. (Lee BJ, et al. Nutr Res. 2012;32:751-6). Featured MMSN Product: MN CoQ10 and Vitamin B6.

MSM Supplementation May Be Beneficial Following Exercise
Methylsulfonylmethane (MSM) has been reported to provide anti-inflammatory and antioxidant effects in mammals. Resistance exercise is known to induce both inflammation and oxidative stress resulting in muscular discomfort and pain. Researchers set out to study the effects of MSM on markers of exercise recovery and performance. In random order, 24 moderately exercise-trained men received MSM supplements at a dose of 3g/day or placebo for 14 days, with a 17-day washout between. The study included three tests: baseline, no product and the 2nd and 3rd following 14 day supplementation with MSM and placebo. Each test consisted of two visits. At the first visit, subjects performed stress exercise of leg extensions of multiple reps to muscular failure. At the second visit (48 hours later), subjects again performed sets and multiple reps of leg extensions to muscle failure. Muscle discomfort/pain, inflammation (hs-CRP & IL-6), blood antioxidant status (TEAC & SOD) and homocysteine were measured before the stressing exercise and 24 and 48 hours post exercise. Exercise performance was also measured following the 14 day supplementation with MSM or placebo. MSM intervention resulted in significantly less pain/discomfort vs. placebo from baseline to 2 hours. Change in IL-6 was significant within the MSM and placebo and between MSM vs. placebo. There were no significant differences between MSM and placebo noted for the other biomarkers. Researchers concluded that MSM may help alleviate the discomfort/pain that can follow a stressful exercise session. (Kalman DS, et al. FASEB J. 2013;27:1076.7). MMSN Featured Product: Max Nutraceuticals MSM 500mg

MULTI-SOURCE PROTEINS
WITH SOY IS AN EFFECTIVE POST-EXERCISE SUPPLEMENT
For years, Max Muscle has promoted the benefits of multi-source proteins for performance and recovery. This recently published study further confirms the benefits of multi-source proteins, which include soy, at the metabolic and molecular level. Researchers hypothesized that a protein blend of soy and dairy proteins would capitalize on the unique properties of each individual protein and allow for optimal delivery of amino acids to prolong the fractional synthetic rate (FSR) following resistance exercise. In this double-blind, randomized, clinical trial, 19 young adults were studied before and after ingestion of 19g of either a soy-dairy protein blend (PB) or 18g whey protein alone consumed one hour after high-intensity leg resistance exercise. Researchers examined mixed-muscle protein FSR and mammalian target of rapamycin (mTORC1) signaling. Whey protein ingestion resulted in higher and earlier amplitude of blood branched-chain amino acid (BCAA) concentrations, but ingestion of the PB created a lower initial rise in blood BCAA but sustained elevated levels of blood amino acids later into recovery. Post-exercise FSR increased equivalently in both groups during the early period. However, FSR remained elevated only in the soy-dairy protein blend group during the late period. mTORC1 signaling similarly increased between groups, except for no increase in S6K1 phosphorylation in the WP group at 5 hours post-exercise. Researchers concluded that a soy-dairy protein blend ingested following exercise is capable of prolonging blood aminoacidemia, mTORC1 signaling, and protein synthesis in human skeletal muscle and is an effective post-exercise nutritional supplement. (Reidy PT, et al. J Nutr. 2013 Apr;143:410-6). MMSN Featured Product: High 5

Yours In Health,
Phillip W. Harvey, PhD, RD, FACN, FISSN
Chief Scientific Officer
Max Muscle Corporate USA

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Dr. Harvey’s Science News for May

Branched-Chain Amino Acids Reduce Muscle Damage

The aim of this study was to examine the effects of a BCAA supplementation on markers of muscle damage elicited via a sport specific bout of damaging exercise in trained volunteers. Twelve males were randomly assigned to a supplement (n = 6) or placebo (n = 6) group. The amaging exercise consisted of 100 consecutive drop-jumps. Creatine kinase (CK), maximal voluntary contraction, muscle soreness (DOMS), vertical jump, thigh circumference and calf circumference were measured as markers of muscle damage. All variables were measured immediately before the damaging exercise and at 24, 48, 72 and 96 hours post-exercise. There were significant group effects showing a reduction in CK efflux and muscle soreness in the BCAA group compared to the placebo. The present study has shown that BCAA administered before and following damaging resistance exercise reduces indices of muscle damage and accelerates recovery in resistance trained males. (Howatson G, et al. J Int Soc Sports Nutr. 2012 8;9:20). MMSN Featured Products: Max BCAA and ARM

CARNOSYN BETA-ALANINE IMPROVES EXERCISE PERFORMANCE IN THE ELDERLY

The aim of this study was to investigate the effects of beta-alanine supplementation on exercise capacity and the muscle carnosine content in elderly subjects. Eighteen healthy elderly subjects ages 60-80 years were randomly assigned to receive either betaalanine (BA) or placebo (PL) for 12 weeks. The BA group received 3.2 g of beta-alanine per day. The PL group received a matched placebo. At baseline, assessments were made of the muscle carnosine content, anaerobic exercise capacity, muscle function, quality of life, physical activity and food intake. A significant increase in the muscle carnosine content of the gastrocnemius muscle was shown in the BA group (+85.4%) when compared with the PL group (+7.2%). The time-to-exhaustion in the constant-load submaximal test (i.e., TLIM) was significantly improved (p=0.05; ES: 1.71) in the BA group (+36.5%) versus the PL group (+8.6%). In summary, the current data indicate for the first time that beta-alanine supplementation is effective in increasing the muscle carnosine content in healthy elderly subjects, with subsequent improvement in their exercise capacity. (del Favero S, et al. Amino Acids. 2012;43:49-56). MMSN Featured Product: Xtinguisher

PEA PROTEIN May Lower Cholesterol at the Gene Level

Researchers set out to evaluate a possible lipid lowering activity of a pea protein isolate and to determine whether pea proteins could affect the hepatic lipid metabolism through regulation of genes involved in cholesterol and fatty acid homeostasis. Rats were fed special high cholesterol diets for 28 days, the protein sources being casein or a pea protein isolate. After 14 and 28 days of dietary treatment, rats fed pea proteins had markedly lower plasma cholesterol and triglyceride levels than rats fed casein (p<0.05). Pea protein-fed rats displayed higher hepatic mRNA levels of LDL receptor versus those fed casein (p<0.05). Hepatic mRNA concentration of genes involved in fatty acids synthesis were lower in pea protein-fed rats than in rats fed casein (p<0.05). The present study demonstrates a marked cholesterol and triglyceride-lowering activity of pea proteins in rats. Moreover, pea proteins appear to affect cellular lipid homeostasis by upregulating genes involved in hepatic cholesterol uptake and by downregulating fatty acid synthesis genes. (Rigamonti E. et al. Mol Nutr Food Res. 2010;54:S24-30). MMSN Featured Product: COMP

Yours In Health,
Phillip W. Harvey, PhD, RD, FACN, CNS
Chief Scientific Officer
Max Muscle Corporate USA

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Dr. Harvey’s Science News

Josse AR, Atkinson SA, Tarnopolsky MA, Phillips SM. Increased consumption of dairy foods and protein during diet-and exercise-induced weight loss promotes fat mass loss and lean mass gain in overweight and obese premenopausal women. J Nutr. 2011 Sep;141:1626-34.

Researchers sought to determine how daily exercise and a reduced-calorie diet varying in total protein and dairy foods affected the composition (i.e., muscle and fat) of weight lost. Ninety otherwise healthy, premenopausal, overweight and obese women who were habitually low dairy consumers were randomized into one of three groups: high protein/high dairy, adequate protein/adequate dairy and adequate protein/low dairy. All participants achieved a net reduction of 750 calories per day through a combination of reducing food intake and increasing exercise.

All groups lost similar amounts of body weight and total body fat over the 16-week study. However, the high protein/high dairy group, which obtained half their protein intake through dairy foods, lost more abdominal fat compared with the adequate protein/low dairy group. This is important to note as there is a strong association between abdominal or centrally located body fat and the risk for cardiovascular disease. The high protein/high dairy group also experienced an increase in lean body mass, while the adequate protein/low dairy group experienced a decrease in lean body mass.

While calorie reduction alone can lead to weight loss, the weight lost often includes not only fat, but also lean muscle. This research supports previous studies showing that higher protein diets during weight loss may help preserve muscle while losing fat. Additionally, this study demonstrates that this higher protein diet can be achieved through an increase in dairy foods.

Read Abstract: http://www.ncbi.nlm.nih.gov/pubmed/21775530

Salehpour A, Shidfar F, Hosseinpanah F, et al. Vitamin D3 and the risk of CVD in overweight and obese women: a randomized controlled trial. Br J Nutr. 2012 Feb 9:1-8.

Evidence indicates that vitamin D deficiency contributes to cardiovascular disease (CVD) and body composition changes. In this study, healthy premenopausal overweight and obese women were randomly supplemented with 1,000 IU (25 mcg) vitamin D3 or placebo for 12 weeks. Results showed that supplementation with vitamin D3 can significantly improve HDL-cholesterol, apoA-I concentrations and LDL-cholesterol:apoB-100 ratio, which remained significant. Additionally, body fat mass was significantly decreased in the vitamin D group more than the placebo.

Read Abstract: http://www.ncbi.nlm.nih.gov/pubmed/22317756

Xu Q, Parks CG, DeRoo LA, et al. Multivitamin use and telomere length in women. Am J Clin Nutr. 2009 Jun;89:1857-63
Telomere length has been proposed as a marker of biological aging. Shorter telomeres have been linked with higher mortality within a given period of time and an increased risk of some chronic diseases. This study was conducted by researchers at the N.I.H. and provides the first epidemiologic evidence that the use of multivitamins by women is associated with longer telomeres: the protective caps at the ends of chromosomes that shorten with the aging of a cell. The researchers found 5.1 percent longer telomeres on average in daily users of multivitamins compared with nonusers. Increased telomere length was associated with one a day and antioxidant formula use, but not with stress-tabs or B complex. Individual vitamin B12 supplements were associated with increased telomere length and iron supplements with shorter telomeres. When nutrients from food were analyzed, vitamins C and E emerged as protective against telomere loss. This study provides preliminary evidence linking multivitamin use to longer telomeres.
Read Abstract: http://www.ncbi.nlm.nih.gov/pubmed/19279081

Yours In Health,
Phillip W. Harvey, PhD, RD, FACN, CNS
Chief Scientific Officer
Max Muscle Corporate USA

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Caffeine, Testosterone & the Other Guy

Not surprisingly, I’ve been besieged by questions regarding weight loss and the proper supplements to make this happen. There is not a one size fits all answer. We had a customer ask where we get the caffeine used in our products like FBXXX and Emerge. I did not know, but told him I would find out.

A: We use a caffeine anhydrous material that is sourced from China but distributed in the U.S. We receive a certificate of analysis (COA) for every lot of raw ingredient purchased that we use in our products no matter where it is sourced, U.S. or any other country. Many raw ingredients used in the supplement industry are only available overseas. Complying to GMP regulations, the COA and raw material are then verified for purity, potency, microbials and heavy metals before it can be used in production. The caffeine anhydrous we use is 100% pure verified by valid and reliable analytical methods. It is also certified Kosher and non-GMO.

Question: what happened to Define 8? Is this new Emerge better or a remade/named version of 8?

A: I am not use if you are referring to a third party product by
Musclewerks we sell in our stores called DFine8 or a product we used to have called De-Lite? I will assume you mean Max Muscle’s De-Lite. When we launched De-Lite feedback was that it was actually too powerful, overengineered and some customers were experiencing GI discomfort due to the high inulin (fructooligosaccharide) content. Since customer feedback is critical to us we decided to reformulate the product and start with a clean slate. Emerge was the outcome and it has been well received by our customers and a huge success with a perfect balance of flavor, strength and performance

Q: I there creams or gel available that boost testosterone? I have read so much about pill form and how ineffective they are.

A: There are testosterone creams or gel products available, but the only FDA approved and effective ones are regulated as drugs. There are no legal creams or gels as dietary supplements that can boost testosterone levels since a dietary supplement must be taken orally. We have a very safe and effective testosterone booster for healthy males called 2TX that is delivered in a capsule. It is a novel and science-based product and has been on the market for some time now with a proven track record. Feedback by males and testimonials have been amazing. I would seriously give 2TX a try.

Yours In Health,
Phillip W. Harvey, PhD, RD, FACN, CNS
Chief Scientific Officer
Max Muscle Corporate USA

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Thank You, The Educated Customer

Satisfaction, when you’re the Chief Science Officer of MMSN, comes when our clients really want to know what is in the supplements they’re taking. I’m happy…

Q: Why don’t we add CLA to the Emerge?

A: CLA stands for Conjugated Linoleic Acid and is a unique polyunsaturated fatty acid (a fat) derived from safflower oil. Clinical research has shown that CLA has significant weight loss benefits. In terms of Emerge, we actually wanted to add it to the formula, but after months in R&D we just could not mask the taste. We tried everything. Real CLA has a strong fatty taste that is very difficult, if not impossible, to mask. We titrated the dose down so low and we could still pick it up off flavor. It would have no beneficial weight loss benefits even at this low dose so we decided to leave it out. Emerge can easily be stacked with our Max CLA.

Q: I was looking at the Whey powder sold at MM. I am wondering why they don’t make any with stevia when that seems to be a much healthier choice. I try to avoid sucralose since studies show it is not a healthy choice.

A: We do make a whey protein without sucralose and it is our Maxpro Natural Vanilla. It is sweetened with Luo Han Fruit Concentrate. We are currently working on an all vegetarian and all natural protein and considering Stevia as the primary sweetener. It should be available sometime this Spring.

Q: I experienced some tingling, much like beta-alanine causes, when I took CNS Black. One of my employees noticed the same thing. Is there anything in the product that may cause the similar effects? Has anyone else mentioned this?

A: The tingling is caused by the main ingredient in CNS Black called GABA (Gamma Aminobutyric Acid). GABA is an amino acid and the tingling sensation is a very characteristic symptom. It is primarily felt on the face, lips, head and neck areas and quickly subsides after a few minutes. It is neuralgic in nature meaning it is a sensation along the course of the nerves especially in the face and head. It is perfectly normal and some like the sensation as a “feel it” ingredient knowing that the product works. Beta-alanine also causes a similar reaction.

Q: Dr. Harvey, Can you help us w/ the dose of melatonin? We had a customer ask today because he already takes melatonin on its own – we were trying to figure out if he should scale back or just omit it w/including CNS Black.

A: Each serving (3 scoops) of CNS Black delivers 3mg melatonin, so there is 1mg per scoop. This dose per serving seems to be the ideal amount for most healthy individuals especially when combined with the other ingredients in the product. Higher doses of melatonin can be used but may cause sluggishness the next day.

Yours In Health,
Phillip W. Harvey, PhD, RD, FACN, CNS
Chief Scientific Officer
Max Muscle Corporate USA

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